The Repurposing of Anti-Psychotic Drugs, Quetiapine and Olanzapine, as Anti-Cryptococcus Drugs

The Repurposing of Anti-Psychotic Drugs, Quetiapine and Olanzapine, as Anti-Cryptococcus Drugs

The management of cryptococcal infections is often difficult. This can, in part, be attributed to the fungistatic nature of fluconazole, which may result in cells disseminating to give rise to pathogen-emergent psychosis following brain inflammation. This chance at treatment failure has necessitated the current study wherein the antimicrobial quality of anti-psychotic drugs viz. quetiapine and ...

Mechanisms of action of anti-psychotic drugs.

Anti-psychotic drugs The anti-psychotic drugs, e.g. haloperidol and chlorpromazine, comprise a large group of drugs that are used to treat the symptoms of schizophrenia [ l ] . The principal therapeutic effect of the drugs is on the positive (psychotic) symptoms of the disorder, although some drugs, e.g. clozapine, are claimed to have effects on the negative symptoms. After the discovery of dop...

Title: Repurposing the anti-psychotic trifluoperazine as an anti-metastasis agent

Repurposing Drugs in Oncology (ReDO)—chloroquine and hydroxychloroquine as anti-cancer agents

Chloroquine (CQ) and hydroxychloroquine (HCQ) are well-known 4-aminoquinoline antimalarial agents. Scientific evidence also supports the use of CQ and HCQ in the treatment of cancer. Overall, preclinical studies support CQ and HCQ use in anti-cancer therapy, especially in combination with conventional anti-cancer treatments since they are able to sensitise tumour cells to a variety of drugs, po...

Therapeutic value of anti-psychotic drugs: A critical analysis of Cochrane meta-analyses of the therapeutic value of anti-psychotic drugs

The Quality of Life Research Center, Copenhagen, Denmark; Research Clinic for Holistic Medicine, Copenhagen, Denmark; Nordic School of Holistic Medicine, Copenhagen, Denmark; Scandinavian Foundation for Holistic Medicine, Sandvika, Norway; Interuniversity College, Graz, Austria; 6National Institute of Public Health, Centre of Alcohol Research, Southern University of Denmark, Copenhagen, Denmark...